Expressive

rs12439802 - SLC28A1 - PDE8A

Magnitude 2.2 · 1 study on file

Reported associations

  • Central Adiposity Increases Risk of Kidney Stone Disease through Effects on Serum Calcium Concentrations - Unknown journal (n.d.) · Unknown authors · PubMed 37787550

    ABSTRACT: Visual Abstract Significance Statement Kidney stone disease is a common disorder with poorly understood pathophysiology. Observational and genetic studies indicate that adiposity is associated with an increased risk of kidney stone disease. However, the relative contribution of general and central adipose depots and the mechanisms by which effects of adiposity on kidney stone disease are mediated have not been defined. Using conventional and genetic epidemiological techniques, we demonstrate that general and central adiposity are independently associated with kidney stone disease. In addition, one mechanism by which central adiposity increases risk of kidney stone disease is by increasing serum calcium concentration. Therapies targeting adipose depots may affect calcium homeostas

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • limit dietary sodium intake Moderate

    high sodium increases urinary sodium and calcium excretion, promoting stone formation in genetically predisposed individuals

    target less than 2300mg sodium daily

Discuss with your doctor

  • kidney stone prevention strategy Moderate

    genetic predisposition to kidney stone disease warrants personalized risk assessment and prevention planning

Lifestyle

  • maintain adequate hydration Moderate

    adequate fluid intake reduces urinary stone-forming ion concentration, primary prevention strategy for kidney stone disease

    aim for 2.5-3 liters water daily

Screening

  • baseline kidney imaging for stone risk Moderate

    rs12439802 G allele increases kidney stone disease risk by 13% per copy; baseline assessment warranted

    renal ultrasound or non-contrast CT scan