Expressive

rs12439545 - LINC02490 - WDR72

Magnitude 2.2 · 1 study on file

Reported associations

  • Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923

    ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • dietary fiber and plant sterols Moderate

    Fiber and plant sterols reduce LDL cholesterol absorption; rs12439545 risk carriers have genetically elevated LDL

    Target 25-30g fiber daily; 2g plant sterols daily

  • excess saturated fat intake Moderate

    Saturated fat raises LDL cholesterol; rs12439545 carriers have baseline elevated LDL susceptibility

    Keep saturated fat to <7% of total calories

Discuss with your doctor

  • cardiovascular risk assessment and statin consideration Moderate

    rs12439545 is a genetic risk factor for elevated LDL cholesterol, a major cardiovascular disease risk factor

    Discuss individual 10-year cardiovascular risk score and statin therapy indications

Exercise

  • regular aerobic exercise Moderate

    Aerobic exercise reduces LDL cholesterol and improves cardiovascular function in those with genetic lipid predisposition

    150 minutes moderate-intensity aerobic activity per week

Screening

  • lipid panel testing Moderate

    rs12439545 elevates LDL cholesterol; regular monitoring tracks phenotype and response to interventions

    Lipid panel every 1-2 years, or annually if LDL elevated