rs12438353 - AGBL1
Magnitude 2.8 · 1 study on file
Reported associations
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Meta-analysis of genome-wide association studies identifies genetic risk factors for stroke in African-Americans - Unknown journal (n.d.) · Unknown authors · PubMed 26089329
ABSTRACT: Background and Purpose The majority of genome-wide association studies (GWAS) of stroke have focused on European-ancestry populations; however, none has been conducted in African-Americans despite the disproportionately high burden of stroke in this population. The Consortium of Minority Population genome-wide Association Studies of Stroke (COMPASS) was established to identify stroke susceptibility loci in minority populations. Methods Using METAL, we conducted meta-analyses of GWAS in 14,746 African-Americans (1,365 ischemic and 1,592 total stroke cases) from COMPASS, and tested SNPs with P<10−6 for validation in METASTROKE, a consortium of ischemic stroke genetic studies in European-ancestry populations. We also evaluated stroke loci previously identified in European-ancestry
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Ischemic stroke risk and prevention strategy Moderate
AGBL1 rs12438353 T allele is associated with 39% increased ischemic stroke risk
Lifestyle
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Regular aerobic exercise Moderate
Aerobic exercise is protective against ischemic stroke, relevant for AGBL1 rs12438353 T allele carriers
150 minutes moderate-intensity aerobic activity weekly
Screening
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Cardiovascular risk factors Moderate
AGBL1 rs12438353 T allele increases ischemic stroke susceptibility; monitoring modifiable risk factors is recommended
Blood pressure, lipid panel, fasting glucose baseline and every 5 years