rs1243578 - RPL15P2 - LINC02279

Magnitude 2.2 · 1 study on file

Reported associations

• Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome‐wide Association Study - Unknown journal (n.d.) · Unknown authors · PubMed 39503264

  ABSTRACT: Abstract Background The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome‐wide association studies (GWASs) have investigated genetic variants determining AAO, particularly in East Asian populations. Objectives To identify single‐nucleotide polymorphisms (SNPs) affecting AAO of PD in Korean patients. Methods We conducted a GWAS on AAO of PD in 1048 Korean patients using sex‐adjusted linear regression models. Additionally, we conducted downstream analyses of our primary GWAS results. Results rs2134545 demonstrated genome‐wide significance (β = −2.459; standard error [SE] = 0.851; P = 1.898 × 10−8) and is an intergenic SNP near the ALCAM gene

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.