rs12427378 - DIP2B

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer - Unknown journal (n.d.) · Unknown authors · PubMed 38408508

  ABSTRACT: Background The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization (MR) analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC. Patients and methods We conducted a GWAS meta-analysis of 6176 EOCRC cases and 65 829 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT), the Colon Cancer Family Registry (CCFR), a

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