Expressive

rs12426511 - OS9-AS1, OS9

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

  • Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects - Unknown journal (n.d.) · Unknown authors · PubMed 30664634

    ABSTRACT: Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. 98 independent associations with body fat distribution are identified, 29 that have not previously been associated with anthropometric traits. A high degree of sex-heterogeneity is observed and the effects of 37 associated variants are stronger in females compared to males. Our findings also implicate that b

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Increase dietary fiber intake Moderate

    High fiber intake improves insulin sensitivity and reduces central fat accumulation and metabolic disease risk.

    Target 25-35g dietary fiber daily from vegetables, fruits, whole grains, and legumes

Exercise

  • Aerobic exercise for trunk fat reduction Moderate

    Aerobic exercise preferentially reduces visceral and trunk fat accumulation and improves metabolic health.

    150-300 minutes per week of moderate-intensity aerobic activity

  • Resistance training for central fat reduction Moderate

    Resistance training reduces visceral fat preferentially while preserving lean body mass and improving metabolic function.

    2-3 sessions per week of resistance or strength training

Screening

  • Waist circumference as central obesity marker Moderate

    Waist circumference directly measures trunk and visceral fat distribution, predicting metabolic disease risk.

    Measure every 3-6 months; target less than 40 inches (men) or 35 inches (women)