rs12426465 - SUDS3 - LINC02460
Magnitude 2.2 · 1 study on file
Reported associations
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Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease - Unknown journal (n.d.) · Unknown authors · PubMed 37985223
ABSTRACT: Abstract INTRODUCTION Although large‐scale genome‐wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. METHODS We conducted a cross‐ancestry GWAS on memory performance (in 27,633 participants) and memory decline (in 22,365 participants; 129,201 observations) by leveraging harmonized cognitive data from four aging cohorts. RESULTS We found high heritability for two ancestry backgrounds. Further, we found a novel ancestry locus for memory decline on chromosome 4 (rs6848524) and three loci in the non‐Hispanic Black ancestry group for memory performance on chromosomes 2 (rs111471504), 7 (rs4142249), and 15 (rs74381744). In our gene‐level analysis, we found novel genes for memory d
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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discuss genetic predisposition to memory decline Moderate
GWAS finding indicates increased memory decline risk; professional guidance on prevention is warranted.
Bring genetic result to healthcare provider for counseling on cognitive health strategies
Exercise
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regular aerobic exercise for memory support Moderate
Aerobic exercise increases cerebral blood flow and neuroplasticity, supporting memory function in those genetically predisposed to decline.
Aim for 150 minutes moderate-intensity aerobic activity per week
Lifestyle
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cognitive training and mental exercise Moderate
Cognitive engagement strengthens memory networks and cognitive reserve, helping maintain function in those with genetic memory decline risk.
Engage in cognitively stimulating activities 20-30 minutes most days (puzzles, learning, strategy games)
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sleep quality and consistency Moderate
Sleep is critical for memory consolidation; consistent sleep is particularly important for those genetically predisposed to memory decline.
Maintain 7-9 hours nightly sleep; track sleep consistency
Screening
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cognitive function screening Moderate
rs12426465 is associated with increased memory decline risk, warranting baseline and periodic cognitive assessment.
Schedule cognitive assessment; discuss re-screening interval with healthcare provider