Expressive

rs12425791 - NINJ2-AS1 - LINC02455

Magnitude 2.8 · 2 studies on file

Reported associations

  • Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer - Unknown journal (n.d.) · Unknown authors · PubMed 29367611

    ABSTRACT: Identifying single nucleotide polymorphisms (SNPs) that influence chemotherapy disposition may help to personalize cancer treatment and limit toxicity. Genome-wide approaches are unbiased, compared with candidate gene studies, but usually require large cohorts. As most chemotherapy is given cyclically multiple blood sampling is required to adequately define drug disposition, limiting patient recruitment. We found that carboplatin and paclitaxel disposition are stable phenotypes in ovarian cancer patients and tested a genome-wide association study (GWAS) design to identify SNPs associated with chemotherapy disposition. We found highly significant SNPs in ABCC2, a known carboplatin transporter, associated with carboplatin clearance (asymptotic P = 5.2 × 106, empirical P 

  • Genomewide Association Studies of Stroke - Unknown journal (n.d.) · Unknown authors · PubMed 19369658

    ABSTRACT: BACKGROUND The genes underlying the risk of stroke in the general population remain undetermined. METHODS We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [±SD] age, 63±8 years) in whom 1544 incident strokes (1164 ischemic strokes) developed over an average follow-up of 11 years. We tested the markers most strongly associated with stroke in a replication cohort of 2430 black persons with 215 incident strokes (191 ischemic strokes), another cohort of 574 black persons with 85 incident strokes (68 ischemic strokes), and 652 Dutch persons with ischemic stroke and 3613 unaffected persons. RESULTS Two intergenic single

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • blood pressure and lipid profile monitoring High

    hypertension and dyslipidemia are major modifiable stroke risk factors in rs12425791 carriers

    at least annually, more frequently if abnormal

Discuss with your doctor

  • individualized stroke prevention and risk management plan High

    elevated ischemic stroke risk from rs12425791 warrants personalized clinical assessment and prevention strategy

Lifestyle

  • regular aerobic exercise and heart-healthy diet High

    cardiovascular fitness and antioxidant-rich diet reduce ischemic stroke risk in genetically predisposed individuals

    150 minutes moderate aerobic activity weekly, Mediterranean-style diet pattern

Screening

  • stroke risk assessment and baseline cardiovascular imaging High

    rs12425791 increases ischemic stroke risk 1.30-1.37 fold through altered neuronal adhesion and regeneration