rs12423717 - TMEM132D - LINC02418

Magnitude 2.0 · 1 study on file

Reported associations

• Host genetic susceptibility to Clostridium difficile infections in patients undergoing autologous stem cell transplantation: a genome-wide association study. - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2019) · Apewokin S, Lee JY, Goodwin JA, McKelvey KD, Stephens OW, Zhou D, Coleman EA · PubMed 29594489

  Clostridium difficile infection (CDI) is the most common hospital-acquired infection. Unfortunately, genes that identify CDI-susceptible patients have not been well described. We performed a genome-wide association study (GWAS) to determine genetic variants associated with the development of CDI. A cohort study of Caucasian patients undergoing autologous stem cell transplantation for multiple myeloma was performed. Patients were genotyped using Illumina® Whole Genome Genotyping Infinium chemistry. We then compared CDI-positive to CDI-negative patients using logistic regression for baseline clinical factors and false discovery rate (FDR) for genetic factors [single nucleotide polymorphisms (SNPs)]. SNPs associated with CDI at FDR of p < 0.01 were then incorporated into a logistic regre

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