rs12423627 - CFAP54

Magnitude 2.2 · 1 study on file

Reported associations

• Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota - Unknown journal (n.d.) · Unknown authors · PubMed 36261456

  ABSTRACT: Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through meta-analyses of genome-wide association studies (GWAS) of two population-based German cohorts. We identified 23 genome-wide significant loci harboring 30 candidate genes involved in innate immune signaling, environmental sensing, cell differentiation, proliferation and fibroblast activity. However, no locus passed the strict threshold for study-wide significance (P < 6.3 × 10−10

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