Expressive

rs12423493 - CRY1 - SETP7

Magnitude 2.2 · 1 study on file

Reported associations

  • Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank. - Nature genetics (2022) · McDonald MN, Lakshman Kumar P, Srinivasasainagendra V, Nair A, Rocco AP, Wilson AC, Chiles JW, Richman JS, Pinson SA, Dennis RA, Jagadale V, Brown CJ, Pyarajan S, Tiwari HK, Bamman MM, Singh JA · PubMed 36411363

    Osteoarthritis is a common progressive joint disease. As no effective medical interventions are available, osteoarthritis often progresses to the end stage, in which only surgical options such as total joint replacement are available. A more thorough understanding of genetic influences of osteoarthritis is essential to develop targeted personalized approaches to treatment, ideally long before the end stage is reached. To date, there have been no large multiancestry genetic studies of osteoarthritis. Here, we leveraged the unique resources of 484,374 participants in the Million Veteran Program and UK Biobank to address this gap. Analyses included participants of European, African, Asian and Hispanic descent. We discovered osteoarthritis-associated genetic variation at 10 loci and replicated

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • osteoarthritis risk management and prevention Moderate

    Genetic variant associated with increased osteoarthritis susceptibility; clinician discussion optimizes personalized prevention strategy

Exercise

  • consistent low-impact exercise program Moderate

    Regular exercise strengthens supporting musculature and maintains cartilage; particularly important given genetic risk

    150 minutes weekly moderate-intensity low-impact activity (walking, swimming, cycling)

Lifestyle

  • maintain healthy body weight Moderate

    Body weight directly impacts joint mechanical loading; genetic risk increases importance of weight management

    monitor BMI; target range 18.5-24.9 per standard guidelines

Screening

  • baseline osteoarthritis joint assessment Moderate

    Genetic risk variant justifies baseline evaluation to establish reference state for future monitoring

    discuss screening approach with primary care or rheumatology provider