rs12422918 - SRGAP1

Magnitude 4.5 · 1 study on file

Reported associations

• Association of CD8 T-cells with bone erosion in patients with rheumatoid arthritis. - International journal of rheumatic diseases (2018) · Joo YB, Park Y, Kim K, Bang SY, Bae SC, Lee HS · PubMed 28512992

  Bone erosion is a major problem worsening quality of rheumatoid arthritis (RA) patients' lives. However, causal factors responsible for bone erosion in RA have remained unclear. We aimed to examine genetic variants conferring bone erosion in RA using a Korean genome-wide association study (GWAS) and to search for possible biological mechanisms underlying the development of bone erosion. We obtained genome-wide single nucleotide polymorphism (SNP) data for 711 Korean RA patients using Illumina HapMap 550v3/660W arrays. Associations between SNPs and bone erosion status based on the Steinbrocker staging system were examined using multivariate logistic regression. Cell-type-specific enrichment of the epigenomic chromatin annotation H3K4me3 at the bone erosion associated variants was further in

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