Expressive

rs12420518 - SIK3

Magnitude 2.2 · 1 study on file

Reported associations

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce refined carbohydrates and added sugars Moderate

    SIK3 eQTL in metabolic tissues suggests carbohydrate metabolism involvement; dietary modification mitigates metabolic dysfunction

    emphasize whole grains, legumes, vegetables; limit sugary beverages and processed foods

Discuss with your doctor

  • rs12420518 metabolic syndrome genetic risk Moderate

    SIK3 T allele is significantly associated with metabolic syndrome; clinical discussion enables risk-aware personalized management

Exercise

  • regular aerobic and resistance exercise Moderate

    Physical activity mitigates metabolic syndrome components and counteracts genetic predisposition

    150 minutes per week moderate-intensity aerobic activity plus 2 sessions per week resistance training

Lifestyle

  • body weight and waist circumference Moderate

    Abdominal adiposity drives metabolic syndrome; genetic risk requires active weight management

    track monthly; target BMI less than 25 kg/m2 and waist less than 40 inches (men) or 35 inches (women)

Screening

  • metabolic syndrome screening Moderate

    T allele significantly increases metabolic syndrome risk in 107,230-person GWAS (p=5.00e-10)

    baseline evaluation and annual monitoring: fasting glucose, lipid panel, blood pressure, waist circumference