Expressive

rs1241657 - SIK3

Magnitude 2.2 · 2 studies on file

Reported associations

  • A Genome-Wide Association Study of Metabolic Syndrome in the Taiwanese Population - Unknown journal (n.d.) · Unknown authors · PubMed 38201907

    ABSTRACT: The purpose of this study was to investigate genetic factors associated with metabolic syndrome (MetS) by conducting a large-scale genome-wide association study (GWAS) in Taiwan, addressing the limited data on Asian populations compared to Western populations. Using data from the Taiwan Biobank, comprehensive clinical and genetic information from 107,230 Taiwanese individuals was analyzed. Genotyping data from the TWB1.0 and TWB2.0 chips, including over 650,000 single nucleotide polymorphisms (SNPs), were utilized. Genotype imputation using the 1000 Genomes Project was performed, resulting in more than 9 million SNPs. MetS was defined based on a modified version of the Adult Treatment Panel III criteria. Among all participants (mean age: 50 years), 23% met the MetS definition. GW

  • Lipidome‐ and Genome‐Wide Study to Understand Sex Differences in Circulatory Lipids - Unknown journal (n.d.) · Unknown authors · PubMed 36193934

    ABSTRACT: Background Despite well‐recognized differences in the atherosclerotic cardiovascular disease risk between men and women, sex differences in risk factors and sex‐specific mechanisms in the pathophysiology of atherosclerotic cardiovascular disease remain poorly understood. Lipid metabolism plays a central role in the development of atherosclerotic cardiovascular disease. Understanding sex differences in lipids and their genetic determinants could provide mechanistic insights into sex differences in atherosclerotic cardiovascular disease and aid in precise risk assessment. Herein, we examined sex differences in plasma lipidome and heterogeneity in genetic influences on lipidome in men and women through sex‐stratified genome‐wide association analyses. Methods and Results We u

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • lipid panel including triglycerides High

    rs1241657 T allele is associated with elevated triacylglycerol levels.

    annual assessment; discuss target levels with physician

Diet

  • refined carbohydrates and added sugars Moderate

    Refined carbohydrates and sugars increase triglyceride synthesis; genetic predisposition requires dietary management.

    emphasize whole grains; limit sugar-sweetened beverages and processed foods

Discuss with your doctor

  • personalized metabolic risk assessment and management plan High

    rs1241657 associates with elevated triglycerides and metabolic syndrome risk.

Exercise

  • aerobic cardiovascular exercise Moderate

    Aerobic activity reduces triglyceride levels; critical for managing genetic risk.

    150 minutes moderate-intensity aerobic activity per week

Screening

  • metabolic syndrome screening Moderate

    rs1241657 C allele is associated with increased metabolic syndrome risk.

    discuss screening criteria: waist circumference, blood pressure, fasting glucose, HDL, triglycerides