Expressive

rs12416116 - RNLS

Magnitude 2.2 · 2 studies on file

Reported associations

  • Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations - Unknown journal (n.d.) · Unknown authors · PubMed 30572963

    ABSTRACT: Background In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component. Methods For this purpose, we performed a cross-disease meta-analysis of Immunochip data from 37,159 patients diagnosed with a seropositive autoimmune disease (11,489 celiac disease (CeD), 15,523 rheumatoid arthritis (RA), 3477 systemic sclerosis (SSc), and 6670 type 1 diabetes (T1D)) and 22,308 healthy controls of European origin using the R package ASSET. Results We identified 38 risk variants shared by at least two of the conditions analyzed, five of which represent new pleiotropic loci in autoim

  • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers - Unknown journal (n.d.) · Unknown authors · PubMed 25751624

    ABSTRACT: Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions (www.T1DBase.org) revealing major pathways contributing to risk, with some loci shared across immune disorders. In order to make genetic comparisons across autoimmune disorders as informative as possible a dense genotyping array, the ImmunoChip, was developed, from which four novel T1D regions were identified (P < 5 × 10−8). A comparative analysis with 15 immune diseases (www.ImmunoBase.org) revealed that T1D is more similar genetically to other autoantibody-positive diseases, most significantly to juvenile idiopathic arthritis and least to ulcerative colitis, and provided support for three additional novel T1D loci. Using a Bayesian approach, we defined credible sets for the T1D SNPs. These T1D

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