rs12415421 - ST8SIA6-AS1, ST8SIA6
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort. - Sleep medicine (2021) · Farias Tempaku P, Leite Santoro M, Bittencourt L, D'Almeida V, Iole Belangero S, Tufik S · PubMed 31786426
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder that has a complex phenotype. Currently, few genes have been linked with OSA. Thus, the aim of this study was to conduct a genome-wide association study (GWAS) of the apnea-hypopnea index (AHI) variation along time (delta-AHI) in a prospective cohort. We used data derived from the São Paulo Epidemiologic Sleep Study (EPISONO) (n = 1074) cohort, which was followed over eight years (n = 712). Our phenotype of interest was delta-AHI and incident OSA. Further, we were interested on the time-dependent effect of genetic variants. Our final GWAS model used delta-AHI as a dependent variable and the SNPs and covariates as independent variables. We also performed a gene-set and pathway analysis. The delta-AHI increased on avera
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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Sleep apnea evaluation and screening Moderate
This variant is associated with increased obstructive sleep apnea risk and progression; airway stability varies with genetic factors
Discuss with doctor about sleep study if symptoms present such as snoring, daytime sleepiness, or witnessed apneas