Expressive

rs12413107 - LINC01435 - LINC02661

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 40708016

    ABSTRACT: Background Alzheimer's disease (AD) risk variants have been identified in European ancestry cohorts that have stronger effects at certain ages, in individuals with a specific sex, or in those with specific isoforms of APOE, the strongest AD risk locus. However, sample sizes in African ancestry (AA) cohorts have been underpowered to perform stratified analyses. Methods We generated genome-wide association study datasets stratified by sex, age at onset (< 75 vs ≥ 75), and APOE-ε4 carrier status in AA cohorts from MVP and the Alzheimer's Disease Genetics Consortium (ADGC). Outcomes in MVP were AD and related dementias (ADRD; n = 4073 cases and 19,648 controls) and proxy dementia (i.e., reported dementia in a parent, n = 6216 cases and 21,566 controls) while ADGC

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Mediterranean diet pattern Moderate

    rs12413107 confers increased Alzheimer's disease risk; Mediterranean-style eating pattern is an established protective dietary intervention for cognitive aging and dementia risk reduction.

    Follow Mediterranean diet pattern: emphasize vegetables, whole grains, fish, olive oil; limit red meat

Discuss with your doctor

  • Alzheimer's disease risk profile and prevention strategy Moderate

    rs12413107 risk allele increases Alzheimer's disease susceptibility; healthcare provider discussion enables individualized screening timeline and risk reduction planning.

Exercise

  • Regular aerobic exercise Moderate

    rs12413107 confers increased Alzheimer's disease risk; aerobic exercise is an established modifiable protective factor for cognitive health and dementia prevention.

    150 minutes per week of moderate-intensity aerobic activity, or 75 minutes per week of vigorous activity

Lifestyle

  • Cognitive engagement and quality sleep Moderate

    rs12413107 confers increased Alzheimer's disease risk; cognitive reserve building and sleep quality are established protective factors for cognitive health.

    Cognitive activities (learning, puzzles, social interaction); maintain 7-9 hours quality sleep nightly

Screening

  • Baseline cognitive assessment and periodic testing Moderate

    rs12413107 risk allele is associated with 1.16-fold increased Alzheimer's disease risk in APOE e4 non-carriers; early detection of cognitive changes enables preventive intervention.

    Establish baseline neuropsychiatric testing by age 50; annual cognitive screening if age 65+