rs12412747 - CRTAC1
Magnitude 2.2 · 1 study on file
Reported associations
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Genetic Associations of Chronotype in the Finnish General Population - Unknown journal (n.d.) · Unknown authors · PubMed 32579418
ABSTRACT: Individuals with a later chronotype (evening types) tend to have unhealthier behaviors and increased morbidity and mortality as compared with those with an earlier chronotype (morning types). However, the role of genetics in explaining evening types' adverse health and health behavior is unclear. Our aim was to study genetic associations of chronotype among 8433 Finns from the cross-sectional National FINRISK 2007 and 2012 studies. First, we studied associations between chronotype and 20 key clock genes with a candidate-gene approach and then performed a full genome-wide association study (GWAS) of chronotype. We also developed a genetic risk score (GRS) for chronotype based on 313 single nucleotide polymorphisms (SNPs) that have previously been associated with chronotype. Chro
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Evening-aligned sleep schedule Moderate
Variant associates with evening chronotype preference; aligning sleep/wake timing with biological tendency supports sleep quality and circadian health
Target sleep 11 PM-1 AM, wake 7 AM-9 AM or later when possible
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Forced early morning wake times Moderate
Genetic evening chronotype tendency conflicts with early wake times, potentially impairing sleep quality and circadian alignment