rs12412038 - NT5C2
Magnitude 2.2 · 1 study on file
Reported associations
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High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study - Unknown journal (n.d.) · Unknown authors · PubMed 35762941
ABSTRACT: Purpose To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. Methods Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. To evaluate the BP versus primary open-angle glaucoma (POAG) relationship, additional Mendelian randomization (MR) analyses were conducted using published GWAS summary statistics. Results Observational analysis revealed a linear relationship between BP traits and IOPcc, with a +0.28 mm Hg increase in IOPcc per 10-mm Hg inc
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to elevated blood pressure High
Carriers of risk allele have significantly increased systolic BP; proactive discussion enables personalized prevention strategy.
Exercise
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regular aerobic exercise High
Aerobic activity reduces blood pressure; critical for managing genetic predisposition to hypertension.
150 minutes moderate intensity or 75 minutes vigorous intensity weekly
Screening
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blood pressure screening High
rs12412038 strongly associated with elevated systolic blood pressure; regular monitoring enables early detection.
Annual screening at minimum; more frequent with additional risk factors