rs12410251 - WNT4 - MIR4418

Magnitude 2.2 · 1 study on file

Reported associations

• MRI-Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites - Unknown journal (n.d.) · Unknown authors · PubMed 40922984

  ABSTRACT: Objective: To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. Methods: We analyzed neck-to-knee MRI data from the UK Biobank (n = 37,589) to measure fat at various locations and used Mendelian randomization to assess effects on 26 obesity-related diseases and 94 biomarkers from FinnGen and other consortia. Result: We identified genetic loci associated with 10 fat depots: abdominal subcutaneous adipose tissue (n = 2 loci), thigh subcutaneous adipose tissue (25), thigh intermuscular adipose tissue (15), visceral adipose tissue (7), liver proton density fat fraction (PDFF) (8), pancreas PDFF (11), paraspinal adipose tissue (9), pelvic bone marrow fat (28), thigh bone marrow fat (27), and vertebrae b

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