Expressive

rs12408851 - LEPR

Magnitude 2.2 · 1 study on file

Reported associations

  • Pleiotropic genetic architecture and novel loci for C-reactive protein levels - Unknown journal (n.d.) · Unknown authors · PubMed 36376304

    ABSTRACT: C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci, we perform multi-trait analysis of genome-wide association studies on C-reactive protein levels along with cardiometabolic traits, followed by a series of in silico analyses including colocalization, phenome-wide association studies and Mendelian randomization. We find 41 novel loci and 19 gene sets associated with C-reactive protein with various pleiotropic effects. Additionally, 41 variants colocalize between C-reactive protein and cardiometabolic risk factors and 12 of them display

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Lipid panel High

    rs12408851 LEPR A-allele increases LDL cholesterol levels, requiring monitoring for cardiovascular risk stratification

    Baseline lipid panel, then annually

    • GWAS_CATALOG:36376304

Diet

  • High saturated fat intake High

    LEPR A-allele increases genetic LDL risk; saturated fat restriction is proven to lower LDL cholesterol

    Limit saturated fat to <7% of daily calories

    • GWAS_CATALOG:36376304

Discuss with your doctor

  • Lipid-lowering therapy consideration Moderate

    Genetic predisposition to elevated LDL may warrant earlier consideration of statin or other lipid-lowering medication based on overall cardiovascular risk

    • GWAS_CATALOG:36376304

Exercise

  • Regular aerobic exercise Moderate

    Physical activity improves HDL, reduces triglycerides, and lowers CVD risk in LEPR A-allele carriers with elevated LDL

    150 minutes per week of moderate-intensity aerobic activity

    • GWAS_CATALOG:36376304