rs12406341 - ATP1B1
Magnitude 2.2 · 1 study on file
Reported associations
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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discuss blood pressure management Moderate
rs12406341-T carriers have increased genetic predisposition to systolic hypertension; early detection and personalized management may reduce cardiovascular complications.
Exercise
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regular aerobic exercise Moderate
Aerobic exercise reduces blood pressure; rs12406341-T carriers with genetic predisposition to elevated BP benefit from evidence-based BP management.
150 minutes moderate or 75 minutes vigorous intensity weekly
Screening
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blood pressure monitoring Moderate
rs12406341-T allele is genome-wide significantly associated with higher systolic blood pressure; carriers have approximately 0.014 SD higher systolic BP.
Annual or per-guideline screening intervals