rs12405634 - RSL24D1P4 - SEPTIN14P21

Magnitude 2.2 · 2 studies on file

Reported associations

• Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa - Unknown journal (n.d.) · Unknown authors · PubMed 31675503

  ABSTRACT: SUMMARY Genomic studies in African populations provide unique opportunities to understand disease etiology, human diversity, and population history. In the largest study of its kind, comprising genome-wide data from 6,400 individuals and whole-genome sequences from 1,978 individuals from rural Uganda, we find evidence of geographically correlated fine-scale population substructure. Historically, the ancestry of modern Ugandans was best represented by a mixture of ancient East African pastoralists. We demonstrate the value of the largest sequence panel from Africa to date as an imputation resource. Examining 34 cardiometabolic traits, we show systematic differences in trait heritability between European and African populations, probably reflecting the differential impact of genes

• Genome-wide analyses of multiple obesity-related cytokines and hormones informs biology of cardiometabolic traits - Unknown journal (n.d.) · Unknown authors · PubMed 34620218

  ABSTRACT: Background A complex set of perturbations occur in cytokines and hormones in the etiopathogenesis of obesity and related cardiometabolic conditions such as type 2 diabetes (T2D). Evidence for the genetic regulation of these cytokines and hormones is limited, particularly in African-ancestry populations. In order to improve our understanding of the biology of cardiometabolic traits, we investigated the genetic architecture of a large panel of obesity- related cytokines and hormones among Africans with replication analyses in African Americans. Methods We performed genome-wide association studies (GWAS) in 4432 continental Africans, enrolled from Ghana, Kenya, and Nigeria as part of the Africa America Diabetes Mellitus (AADM) study, for 13 obesity-related cytokines and hormones, in

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