rs12404526 - PTPRU

Magnitude 2.2 · 1 study on file

Reported associations

• Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. - The American journal of clinical nutrition (2022) · Krupenko SA, Cole SA, Hou R, Haack K, Laston S, Mehta NR, Comuzzie AG, Butte NF, Voruganti VS · PubMed 35460232

  Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme, and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the 10-formyltetrahydrofolate dehydrogenase enzyme in serine-to-glycine conversion. We sought to determine the genomic influence on the serine-glycine ratio in 803 Hispanic children from 319 families of the Viva La Familia cohort. We performed a genome-wide association analysis for plasma serine, glycine, and the serine-glycine ratio in Sequential Oligogenic Linkage Analysis Routines while accounting for relationships among family members. All 3 para

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