rs12404302 - LINC01725
Magnitude 4.5 · 1 study on file
Reported associations
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rs2671655 single nucleotide polymorphism modulates the risk for gastric cancer in Helicobacter pylori-infected individuals: a genome-wide association study in the Korean population - Unknown journal (n.d.) · Unknown authors · PubMed 35325318
ABSTRACT: Objective To identify genetic variations which is associated with gastric cancer (GC) risk according to Helicobacter pylori infection. Methods This study incorporated 527 GC patients and 441 controls from a cohort at Seoul National University Bundang Hospital. The associations between GC risk and single nucleotide polymorphisms were calculated, stratified by H. pylori status, adjusting for age, sex, and smoking. mRNA expression from non-cancerous gastric mucosae was evaluated using reverse transcription quantitative polymerase chain reaction. Results In the entire cohort, genome-wide association study showed no significant variants reached the genome-wide significance level. In the H. pylori-positive group, rs2671655 (chr17:47,468,020;hg19, GH17J049387 enhancer region) was iden
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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gastric cancer surveillance if H. pylori positive Moderate
This variant is associated with 2.75-fold increased diffuse gastric cancer risk in H. pylori positive carriers.
If H. pylori positive, discuss gastric cancer surveillance protocols with gastroenterologist.