rs1239055408 - CALM2P1 - CASC17

Magnitude 2.2 · 1 study on file

Reported associations

• Twelve Loci Associated With Bone Density in Middle-aged and Elderly Chinese: The Shanghai Changfeng Study. - The Journal of clinical endocrinology and metabolism (2023) · Zeng H, Ge J, Xu W, Ma H, Chen L, Xia M, Pan B, Lin H, Wang S, Gao X · PubMed 36228083

  Previous genome-wide association studies (GWASs) of bone mineral density (BMD) were mainly conducted in Europeans. To explore genetic variants that affect BMD and sex differences in a Chinese population. A total of 5428 middle-aged and elderly Chinese were included. Dual-energy X-ray absorptiometry was used to measure BMD at the lumbar spine, and total and specific sites of the hip. A mixed linear model was used to analyze the associations between BMD and autosomal genetic variants, adjusting for age, age squared, sex, and menopausal women (model 1); model 2 was further adjusted for height and weight. A GWAS of osteoporosis in the Biobank Japan (BBJ) project was used for replication. GWAMA software was used to detect the statistical significance of sex differences of estimated effects. Gen

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