rs12372954 - DTWD1 - ATP8B4

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • enhanced UV protection and sun avoidance Moderate

    rs12372954 risk variants associate with actinic keratosis susceptibility; actinic keratosis is primarily UV-driven, so photoprotection reduces risk

    daily broad-spectrum SPF 30+ sunscreen, protective clothing, avoid peak sun hours (10am-4pm)

Screening

  • dermatological screening for actinic keratosis Moderate

    rs12372954 is associated with increased actinic keratosis risk; periodic skin screening enables early detection of UV-induced precancerous lesions

    discuss screening frequency with dermatologist; baseline exam in 30s-40s