rs12367822 - HSD17B6 - SDR9C7

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide meta-analyses identifies 7 loci associated with platelet aggregation in response to agonists - Unknown journal (n.d.) · Unknown authors · PubMed 20526338

  [INTRO] Platelet function mediates both beneficial and harmful effects on human health, but few genes are known to contribute to variability in the process. We tested association of 2.5 million SNPs with platelet aggregation responses to 3 agonists (ADP, epinephrine and collagen) in two European-ancestry cohorts (N ≤ 2,753 in the Framingham Heart Study, N ≤ 1,238 in the Genetic Study of Atherosclerosis Risk), with replication (P < 0.05) in an African-American cohort (N ≤ 840 in the Genetic Study of Atherosclerosis Risk). We identified associations of seven loci with platelet aggregation, near/in GP6 (P = 4.6×10−13), PEAR1 (P = 3.4×10−12), ADRA2A (P = 3.3×10−11), PIK3CG (P = 3.1×10−9), JMJD1C (P = 1.6×10−8), MRVI1 (P = 2.0×10−8), and SHH (P = 4.5×10−8). Evidence o

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