rs12364720 - SPON1
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration - Unknown journal (n.d.) · Unknown authors · PubMed 32242144
ABSTRACT: Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identify 143 independent loci in 112 1-Mb regions, providing insights into the physiology of vitamin D and implicating genes involved in lipid and lipoprotein metabolism, dermal tissue properties, and the sulphonation and glucuronidation of 25OHD. Mendelian randomization models find no robust evidence that 25OHD concentration has causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes have (direct or indirect) causal effects on 25OHD concentration, clarifying the epidemiological relationship between 25OHD status and the health outcomes examined in this s
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Bloodwork
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serum 25-hydroxyvitamin D level High
rs12364720 T allele is associated with significantly lower vitamin D levels (p=5e-13, n=177k GWAS)
Annual or semi-annual testing, target level 30-50 ng/mL
Lifestyle
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regular midday sun exposure for vitamin D synthesis Moderate
Natural skin vitamin D production helps offset genetic predisposition to lower circulating levels
15-30 minutes of midday sun exposure 3-4 times weekly when feasible
Supplements
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vitamin D3 supplementation Moderate
T allele carriers have genetically reduced serum vitamin D levels requiring supplementation to maintain adequate status
1000-2000 IU daily if serum levels below 30 ng/mL, adjust based on testing