rs12362449 - LINC01395 - TMEM45B

Magnitude 4.5 · 1 study on file

Reported associations

• Genotype-Phenotype Models Predicting V̇O 2max Response to High-Intensity Interval Training in Physically Inactive Chinese. - Medicine and science in sports and exercise (2023) · Yang X, Li Y, Bao D, Mei T, Wuyun G, Zhou D, Nie J, Xia X, Liu X, He Z · PubMed 37170954

  This study aimed to analyze the interindividual differences of the maximal oxygen uptake (V̇O 2max ) response to 12 wk of high-intensity interval training (HIIT), and the genotype-phenotype models were constructed to predict the effect of HIIT on V̇O 2max . A total of 228 physically inactive adults who completed a 12-wk HIIT were analyzed. A genome-wide association study (GWAS) was conducted to identify genetic variants associated with the V̇O 2max response. Nonresponders, responders, and the highest training responders were defined as the effect sizes (ES) <0.2, ≥0.2, and ≥0.8, respectively. We generated polygenic predictor score (PPS) using lead variants and constructed a predictive model for V̇O 2max response based on a linear stepwise regression analysis. The V̇O 2max increase

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