rs12362063 - LINC02742 - LINC02755

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections - Unknown journal (n.d.) · Unknown authors · PubMed 28928442

    ABSTRACT: Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P < 5 × 10−8) associations in genes with key roles


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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Hepatitis B prevention strategy given genetic risk Moderate

    This SNP is associated with increased Hepatitis B susceptibility, warranting enhanced preventive discussion

    Discuss genetic findings and whether additional screening, vaccination boosters, or monitoring are appropriate

Screening

  • Hepatitis B vaccination and immunity status Moderate

    GWAS variant associated with increased Hepatitis B infection susceptibility

    Confirm vaccination records; consider anti-HBs titer testing if immunity uncertain