rs12360992 - ANKK1
Magnitude 2.2 · 1 study on file
Reported associations
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Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study - Unknown journal (n.d.) · Unknown authors · PubMed 37156939
ABSTRACT: Background and Aims: Genome-wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sought to identify novel loci for substance use traits (SUTs) in both African- (AFR) and European- (EUR) ancestry individuals to enhance our understanding of the traits' genetic architecture. Design: We used multi-trait analysis of GWAS (MTAG) to analyze four SUTs in EUR subjects (OUD, CUD, AUD and smoking initiation [SMKinitiation]), and three SUTs in AFR subjects (OUD, AUD and smoking trajectory [SMKtrajectory]). We conducted gene-set and protein-protein interaction analyses and calculated polygenic risk scores (PRS) in two independent samples
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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alcohol use disorder genetic risk assessment and family history Moderate
ANKK1 variation confers genetic risk; clinician discussion enables informed prevention strategy.
Discuss family history of alcohol misuse and genetic predisposition with healthcare provider.
Lifestyle
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weekly alcohol consumption Moderate
ANKK1 rs12360992 associated with alcohol use disorder risk; genetic predisposition warrants close monitoring.
Track weekly consumption; maintain within recommended guidelines (<=14 units/week males, <=7 units/week females).