rs12358475 - ECHDC3 - PROSER2

Magnitude 2.8 · 1 study on file

Reported associations

• A Genome Wide Meta-Analysis Study for Identification of Common Variation Associated with Breast Cancer Prognosis - Unknown journal (n.d.) · Unknown authors · PubMed 25526632

  ABSTRACT: Objective Genome wide association studies (GWAs) of breast cancer mortality have identified few potential associations. The concordance between these studies is unclear. In this study, we used a meta-analysis of two prognostic GWAs and a replication cohort to identify the strongest associations and to evaluate the loci suggested in previous studies. We attempt to identify those SNPs which could impact overall survival irrespective of the age of onset. Methods To facilitate the meta-analysis and to refine the association signals, SNPs were imputed using data from the 1000 genomes project. Cox-proportional hazard models were used to estimate hazard ratios (HR) in 536 patients from the POSH cohort (Prospective study of Outcomes in Sporadic versus Hereditary breast cancer) and 805 pa

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