Expressive

rs12356492 - LINC02676 - LINC00709

Magnitude 2.0 · 2 studies on file

Reported associations

  • Genetic relationships between high blood eosinophil count, asthma susceptibility, and asthma severity. - The Journal of asthma : official journal of the Association for the Care of Asthma (2024) · Li H, Li X · PubMed 37560908

    Genetic relationships between blood eosinophil count (BEC), asthma susceptibility, and severity are unclear. We sought to identify the genetic difference between type 2 (T2) and nontype 2 (non-T2) asthma (defined by BEC) and investigate genetic relationships between high BEC, asthma susceptibility, and severity. Genome-wide association studies (GWASs) were performed for T2 ( = 9,064; BEC ≥ 300 cells/μL) versus non-T2 asthma ( = 14,379; BEC < 150 cells/μL) and asthma susceptibility (37,227 asthmatics vs. 124,132 nonasthma controls) in the UK Biobank and asthma severity (moderate-to-severe asthma [ = 2,153] vs. mild asthma [ = 5165]) in the All of Us Research Program (AoURP). Genetic causality between BEC, asthma susceptibility, and severity were dissected using Mendelian randomi

  • Shared Genetic and Experimental Links between Obesity-Related Traits and Asthma Subtypes in UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 31669095

    ABSTRACT: Background: Clinical and epidemiological studies have shown that obesity is associated with asthma and that these associations differ by asthma subtypes. Little is known about the shared genetic components between obesity and asthma. Objective: To identify shared genetic associations between obesity-related traits and asthma subtypes in adults. Methods: A cross-trait genome-wide association study (GWAS) was performed using 457,822 individuals of European ancestry from the UK Biobank. Experimental evidence to support the role of genes significantly associated with both obesity-related traits and asthma via GWAS was sought using results from obese vs. lean mouse RNA-seq and RT-PCR experiments. Results: We found a substantial positive genetic correlation between BMI and later-onset

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