Expressive

rs12355158 - KIF11

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus - Unknown journal (n.d.) · Unknown authors · PubMed 38685053

    ABSTRACT: Background The genetic basis of type 2 diabetes (T2D) is under-investigated in the Middle East, despite the rapidly growing disease prevalence. We aimed to define the genetic determinants of T2D in Qatar. Methods Using whole genome sequencing of 11,436 participants (2765 T2D cases and 8671 controls) from the population-based Qatar Biobank (QBB), we conducted a genome-wide association study (GWAS) of T2D with and without body mass index (BMI) adjustment. Results We replicated 93 known T2D-associated loci in a BMI-unadjusted model, while 96 known loci were replicated in a BMI-adjusted model. The effect sizes and allele frequencies of replicated SNPs in the Qatari population generally concurred with those from European populations. We identified a locus specific to our cohort locate

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Refined carbohydrates and added sugars High

    Refined carbs and sugars cause rapid glucose spikes and reduce insulin sensitivity, particularly problematic with KIF11-associated genetic risk

    Limit refined grains, sugary beverages, desserts; prioritize whole grains, legumes, and fiber

Lifestyle

  • Regular aerobic physical activity High

    Exercise improves insulin sensitivity and glucose control, reducing Type 2 diabetes risk in genetically predisposed individuals

    150 minutes moderate-intensity aerobic activity weekly, plus resistance training 2-3 times weekly

Screening

  • Type 2 diabetes screening High

    KIF11 variant rs12355158 is strongly associated with Type 2 diabetes risk, warranting regular monitoring for early detection and intervention

    Annual fasting glucose and HbA1c testing; more frequent if symptomatic