Expressive

rs12354087 - RABGAP1L

Magnitude 2.2 · 1 study on file

Reported associations

  • Novel genetic loci associated with osteoarthritis in multi-ancestry analyses in the Million Veteran Program and UK Biobank. - Nature genetics (2022) · McDonald MN, Lakshman Kumar P, Srinivasasainagendra V, Nair A, Rocco AP, Wilson AC, Chiles JW, Richman JS, Pinson SA, Dennis RA, Jagadale V, Brown CJ, Pyarajan S, Tiwari HK, Bamman MM, Singh JA · PubMed 36411363

    Osteoarthritis is a common progressive joint disease. As no effective medical interventions are available, osteoarthritis often progresses to the end stage, in which only surgical options such as total joint replacement are available. A more thorough understanding of genetic influences of osteoarthritis is essential to develop targeted personalized approaches to treatment, ideally long before the end stage is reached. To date, there have been no large multiancestry genetic studies of osteoarthritis. Here, we leveraged the unique resources of 484,374 participants in the Million Veteran Program and UK Biobank to address this gap. Analyses included participants of European, African, Asian and Hispanic descent. We discovered osteoarthritis-associated genetic variation at 10 loci and replicated

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Osteoarthritis risk stratification and early intervention Moderate

    Genetic risk assessment informs personalized prevention strategy including screening timeline and targeted modifiable risk factor management

    Discuss with physician: baseline risk assessment, screening plan, and prevention strategies

Exercise

  • Regular low-impact strengthening exercise Moderate

    Strengthens periarticular muscles to stabilize joints; improves proprioception and may slow osteoarthritis progression

    150 min moderate aerobic + resistance 2x/week, include stretching and balance training

Lifestyle

  • Maintain healthy weight for joint protection Moderate

    Weight is a modifiable risk factor for osteoarthritis progression; managing weight reduces mechanical load on joints

    Target BMI 18.5-24.9 kg/m2; consult physician or registered dietitian for personalized strategies

Screening

  • Osteoarthritis screening and joint assessment Moderate

    Genetic variant associated with significantly increased osteoarthritis risk; early identification enables preventive intervention

    Baseline joint exam at age 40 or per physician; discuss follow-up imaging timing based on symptoms and risk