Expressive

rs12351118 - SEMA4D - GADD45G

Magnitude 2.2 · 1 study on file

Reported associations

  • Polygenic Hyperlipidemias and Coronary Artery Disease Risk - Unknown journal (n.d.) · Unknown authors · PubMed 32154731

    ABSTRACT: Supplemental Digital Content is available in the text. Background: Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LDL-C) or triglyceride (TG)-increasing variants associates with increased CAD risk. Methods: We derived polygenic risk scores (PRSs) with ≈6M variants separately for LDL-C and TG with weights from a UK Biobank-based genome-wide association study with ≈324K samples. We evaluated the impact of polygenic hypercholesterolemia and hypertriglyceridemia to lipid levels in 27 039 individuals from the National FINRISK Study

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Bloodwork

  • Fasting triglyceride levels Moderate

    rs12351118 is associated with increased triglyceride levels in large GWAS; GADD45G expression changes may influence lipid metabolism across adipose and metabolic tissues

    Annual or biannual fasting lipid panel

Diet

  • Reduce refined carbohydrates and added sugars Moderate

    High refined carbohydrate intake raises triglycerides; genetic variant associated with elevated baseline triglycerides

    Emphasize whole grains and legumes; limit sugary beverages and refined breads

Discuss with your doctor

  • Cardiovascular risk and triglyceride management strategy Moderate

    Genetic predisposition to higher triglycerides may interact with lifestyle factors to influence cardiovascular risk trajectory

    Discuss personalized risk profile, dietary modifications, and follow-up monitoring approach