rs12346733 - RMI1 - SLC28A3

Magnitude 2.2 · 1 study on file

Reported associations

• ADuLT: An efficient and robust time-to-event GWAS - Unknown journal (n.d.) · Unknown authors · PubMed 37689771

  ABSTRACT: Proportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under different generative models and when ascertainment is present. Here we propose the age-dependent liability threshold (ADuLT) model as an alternative to a Cox regression based GWAS, here represented by SPACox. We compare ADuLT, SPACox, and standard case-control GWAS in simulations under two generative models and with varying degrees of ascertainment as well as in the iPSYCH cohort. We find Cox regression GWAS to be underpowered when cases are strongly ascertained (cases are oversampled by a factor 5), regardless of the generative model used. ADuL

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