rs12344176 - GLIS3

Magnitude 2.2 · 1 study on file

Reported associations

• The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA? - Clinical orthopaedics and related research (2019) · MacInnes SJ, Hatzikotoulas K, Fenstad AM, Shah K, Southam L, Tachmazidou I, Hallan G, Dale H, Panoutsopoulou K, Furnes O, Zeggini E, Wilkinson JM · PubMed 30794219

  Periprosthetic osteolysis resulting in aseptic loosening is a leading cause of THA revision. Individuals vary in their susceptibility to osteolysis and heritable factors may contribute to this variation. However, the overall contribution that such variation makes to osteolysis risk is unknown. We conducted two genome-wide association studies to (1) identify genetic risk loci associated with susceptibility to osteolysis; and (2) identify genetic risk loci associated with time to prosthesis revision for osteolysis. The Norway cohort comprised 2624 patients after THA recruited from the Norwegian Arthroplasty Registry, of whom 779 had undergone revision surgery for osteolysis. The UK cohort included 890 patients previously recruited from hospitals in the north of England, 317 who either had ra

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