rs12340460 - CDKN2B-AS1 - DMRTA1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association meta-analysis identifies two novel loci associated with dental caries - Unknown journal (n.d.) · Unknown authors · PubMed 39192244
ABSTRACT: Background Tooth loss significantly impacts oral function and overall health deterioration. Dental caries and periodontal disease are major contributors to tooth loss, emphasizing the critical need to prevent these conditions. Genetic studies have played a crucial role in deepening our understanding of the underlying mechanisms of these diseases. While large-scale genome-wide association studies (GWAS) on dental caries and periodontal disease have been conducted extensively, research focusing on Asian populations remains limited. Given substantial genetic and lifestyle variations across ethnicities, conducting studies across diverse populations is imperative. This study aimed to uncover new insights into the genetic mechanisms of these diseases, contributing to broader knowledge
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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sugary and acidic foods and drinks Moderate
High caries risk from genetic predisposition requires dietary control to reduce bacterial acid production.
limit to meal times; rinse mouth after acidic foods
Lifestyle
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enhanced oral hygiene practices Moderate
Increased dental caries risk from rs12340460 risk allele requires proactive plaque control and prevention.
brush twice daily with fluoride toothpaste; floss daily; consider electric toothbrush
Screening
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more frequent dental checkups for caries prevention Moderate
CDKN2B-AS1/DMRTA1 region strongly associated with dental caries susceptibility; enhanced screening can enable early intervention.
discuss with dentist; consider 3-4 month intervals instead of standard 6 months