rs12334545 - BIN3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association of individual vulnerability with alcohol-associated liver disease: A Korean genome and epidemiology study. - Hepatology (Baltimore, Md.) (2022) · Kim KY, Kim JO, Kim YS, Choi JE, Park JM, Han K, Park DH, Park YC, Kim BT, Hong KW · PubMed 34387878

  The quantity of alcohol leading to alcohol-associated liver disease (ALD) varies individually. Genetic backgrounds contributing to the divergence in individual susceptibility to alcohol-induced liver damage have not been elucidated in detail. Based on the Korean Genome and Epidemiology Study Health Examination (KoGES_HEXA) cohort data, 21,919 participants (40-79 years old) were included and divided into cases and controls based on the ALD diagnostic criteria proposed by the American College of Gastroenterology. Data generated by a genome wide-association study were analyzed using logistic regression to assess the risk of ALD development in nondrinkers, light drinkers, and heavy drinkers. We detected three loci, gamma-glutamyltransferase 1 (GGT1), zinc protein finger 827 (ZNF827) and HNF1 h

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