rs12333983 - CYP3A7 - CYP3A4

Magnitude 2.2 · 1 study on file

Reported associations

• An Integrated Clinical and Genetic Prediction Model for Tacrolimus Levels in Pediatric Solid Organ Transplant Recipients - Unknown journal (n.d.) · Unknown authors · PubMed 33755393

  ABSTRACT: Background. There are challenges in achieving and maintaining therapeutic tacrolimus levels after solid organ transplantation (SOT). The purpose of this genome-wide association study was to generate an integrated clinical and genetic prediction model for tacrolimus levels in pediatric SOT. Methods. In a multicenter prospective observational cohort study (2015-2018), children <18 years old at their first SOT receiving tacrolimus as maintenance immunosuppression were included (455 as discovery cohort; 322 as validation cohort). Genotyping was performed using a genome-wide single nucleotide polymorphism (SNP) array and analyzed for association with tacrolimus trough levels during 1-y follow-up. Results. Genome-wide association study adjusted for clinical factors identified 25 SNPs

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