rs12330587 - FNDC3B
Magnitude 2.2 · 1 study on file
Reported associations
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Beyond apples and pears: sex-specific genetics of body fat percentage - Unknown journal (n.d.) · Unknown authors · PubMed 37867527
ABSTRACT: Introduction Biological sex influences both overall adiposity and fat distribution. Further, testosterone and sex hormone binding globulin (SHBG) influence adiposity and metabolic function, with differential effects of testosterone in men and women. Here, we aimed to perform sex-stratified genome-wide association studies (GWAS) of body fat percentage (BFPAdj) (adjusting for testosterone and sex hormone binding globulin (SHBG)) to increase statistical power. Methods GWAS were performed in white British individuals from the UK Biobank (157,937 males and 154,337 females). To avoid collider bias, loci associated with SHBG or testosterone were excluded. We investigated association of BFPAdj loci with high density cholesterol (HDL), triglyceride (TG), type 2 diabetes (T2D), coronary ar
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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body fat percentage Moderate
FNDC3B rs12330587 is associated with increased body fat percentage, suggesting heightened metabolic risk predisposition.
Annual measurement via DEXA, bioelectrical impedance, or clinical assessment