rs12326005 - NMT1
Magnitude 2.2 · 1 study on file
Reported associations
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An atlas of genetic influences on osteoporosis in humans and mice - Unknown journal (n.d.) · Unknown authors · PubMed 30598549
ABSTRACT: Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound (eBMD) in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with eBMD, in ~1.2M individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds-ratio=58, p=10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice lacking target genes and found an increased abnormal skeletal phenotype frequency compared to 526
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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calcium-rich foods or supplementation Moderate
Calcium essential for bone matrix mineralization; critical for individuals with genetic BMD reduction
1000-1200 mg daily from food sources; supplement if dietary intake insufficient
Exercise
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weight-bearing and resistance exercise Moderate
Mechanical loading activates osteoblasts and stimulates bone formation
30+ minutes moderate intensity 4-5 days per week; include resistance training
Screening
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bone mineral density screening Moderate
G risk allele causes lower heel bone mineral density, increasing fracture risk
DEXA scan or heel ultrasound; baseline assessment, repeat per clinical protocol