rs12319493 - TRHDE - LINC02444

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide imaging association study implicates functional activity and glial homeostasis of the caudate in smoking addiction - Unknown journal (n.d.) · Unknown authors · PubMed 28927378

  ABSTRACT: Background Nearly 6 million deaths and over a half trillion dollars in healthcare costs worldwide are attributed to tobacco smoking each year. Extensive research efforts have been pursued to elucidate the molecular underpinnings of smoking addiction and facilitate cessation. In this study, we genotyped and obtained both resting state and task-based functional magnetic resonance imaging from 64 non-smokers and 42 smokers. Smokers were imaged after having smoked normally ("sated") and after having not smoked for at least 12 h ("abstinent"). Results While abstinent smokers did not differ from non-smokers with respect to pairwise resting state functional connectivities (RSFCs) between 12 brain regions of interest, RSFCs involving the caudate and putamen of sated smokers sign

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