rs12313180 - TMTC1 - LINC02386

Magnitude 2.0 · 1 study on file

Reported associations

• PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile. - Respiration; international review of thoracic diseases (2021) · Hosgood Iii HD, Díaz-Peña R, Blansky D, Jaime S, Parra V, Boekstegers F, Bermejo JL, García-Valero J, Montes JF, Valdivia G, Miravitlles M, Agustí À, Silva RS, Olloquequi J · PubMed 32222710

  Genome-wide association studies (GWAS) have accelerated our understanding of the genetic underpinnings of chronic obstructive pulmonary disease (COPD); however, GWAS populations have typically consisted of European descent, with ∼1% of Latin American ancestry. To overcome this limitation, we conducted a GWAS in a rural Chilean population with increased COPD risk to investigate genetic variation of COPD risk in this understudied minority population. We carried out a case-control study of 214 COPD patients (defined by the GOLD criteria) and 193 healthy controls in Talca, Chile. DNA was extracted from venous blood and genotyped on the Illumina Global Screening Array (n = 754,159 markers). After exclusion based on Hardy-Weinberg equilibrium (p ≤ 0.001), call rates (<95%), and minor allele

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