Expressive

rs1231206 - SMG6

Magnitude 2.2 · 1 study on file

Reported associations

  • Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease - Unknown journal (n.d.) · Unknown authors · PubMed 21378990

    ABSTRACT: We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 cases and 64,762 controls of European descent, followed by genotyping of top association signals in 60,738 additional individuals. This genomic analysis identified 13 novel loci harboring one or more SNPs that were associated with CAD at P<5×10−8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 novel loci displayed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6 to 17 percent increase in the risk of CAD per allele. Notably, only three of the novel loci displayed significant association with traditional CAD risk factors, while the majority lie in gene regions not previously implicated in the pathogenes

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • CHD genetic risk and family history with physician Moderate

    SMG6-A allele significantly increases coronary heart disease risk; personalized risk assessment based on family history guides prevention intensity

    review early-onset CHD in family; consider formal genetic risk assessment if positive family history

Exercise

  • aerobic exercise for cardiovascular protection Moderate

    Physical activity reduces coronary heart disease risk; particularly important given SMG6-A carriers have baseline 7 percent increased CHD risk

    150 minutes moderate-intensity or 75 minutes vigorous-intensity aerobic activity per week

Screening

  • cardiovascular risk assessment starting at age 30 Moderate

    SMG6 rs1231206-A allele associates with 1.07x increased coronary heart disease risk in large GWAS cohort (n=86,995), warranting early risk stratification

    baseline EKG and blood pressure; discuss lipid panel and coronary artery calcium scoring with physician