rs12305809 - ZNF268
Magnitude 2.2 · 1 study on file
Reported associations
-
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925
ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo
Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.
Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
-
Structured weight loss and regular aerobic exercise Moderate
Lifestyle interventions substantially reduce T2D risk, especially important given genetic predisposition from this variant
150 minutes moderate-intensity aerobic activity per week; aim for 5-7% weight loss if overweight
Screening
-
Type 2 diabetes screening Moderate
rs12305809-G allele increases Type 2 diabetes risk; early detection and intervention improve outcomes
HbA1c measurement every 1-2 years; annual if BMI >25 or age >45