rs12303914 - KLRD1
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans - Unknown journal (n.d.) · Unknown authors · PubMed 23400010
ABSTRACT: Hydrochlorothiazide (HCTZ) is one of the most widely prescribed antihypertensive medications. Although it is well known that HCTZ is associated with hyperglycemia and hypertriglyceridemia, the mechanisms underlying these adverse effects are not well understood. We performed a genome-wide association study and meta-analysis of the change in fasting plasma glucose and triglycerides in response to HCTZ from two different clinical trials: the Pharmacogenomic Evaluation of Antihypertensive Responses and the Genetic Epidemiology of Responses to Antihypertensive studies. Two single-nucleotide polymorphisms (rs12279250 and rs4319515 (r2=0.73)), located at 11p15.1 in the NELL1 gene, achieved genome-wide significance for association with change in fasting plasma triglycerides in African Am
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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thiazide diuretic alternative options Moderate
KLRD1 rs12303914 A allele associates with increased adverse metabolic effects when taking thiazide diuretics
If diagnosed with hypertension requiring medication, discuss alternatives to thiazide diuretics with your doctor