rs12300786 - PCED1B - PPIAP45

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide Analysis of Genetic Predisposition to Common Polygenic Cancers - Unknown journal (n.d.) · Unknown authors · PubMed 34981446

  ABSTRACT: Lung, breast, prostate, and colorectal cancers are among the most common and fatal malignancies worldwide. They are mainly caused by multifactorial mechanisms and are genetically heterogeneous. We investigated the genetic architecture of these cancers through genome-wide association, pathway-based, and transcriptome-/methylome-wide association analyses using three independent cohorts. Our genome-wide association analyses identified the associations of 33 single-nucleotide polymorphisms (SNPs) at P < 5E-06, of which 32 SNPs were not previously reported and did not have proxy variants within their ±1 Mb flanking regions. Moreover, other polymorphisms mapped to their closest genes were not previously associated with the same cancers at P < 5E-06. Our pathway enrichment analyses rev

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